Abstract T P302: Acute Kidney Injury in Subarachnoid hemorrhage is Associated with Higher Death and Disability
Background: Acute kidney injury (AKI) in setting of subarachnoid hemorrhage (SAH) maybe associated with higher mortality.
Objective: To determine the effect of AKI on outcomes of SAH patients treated in a large national cohort.
Methods: We analyzed data from all patients admitted to US hospitals between 2005 and 2011 with a primary discharge diagnosis of SAH and secondary diagnosis of AKI. The effect of AKI on discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis.
Results: Of 173053 patients with SAH, 8302 (4.8%) had AKI. In AKI group, 290 (3.5%) patients were on dialysis. SAH patients with AKI had higher rates of moderate to severe disability (40.7% versus 36.6% p=<0.0001) and in-hospital mortality (39.4% versus 20.1% p=<0.0001) compared to those without AKI. After adjusting for potential confounders SAH patients with AKI had higher odds of moderate to severe disability [odds ratio (OR) 1.3, 95% confidence interval (CI) (1.1-1.5, p= 0.02)] and death [(OR) 2.0, 95% (CI) (1.8-2.3, p=<0.0001)].
Conclusion: AKI in patients with SAH is associated with significantly higher rates of death and disability. It remains unclear whether aggressive fluid replacement and bicarbonate administration can reduce the high rates ofadverse outcomes. .
Author Disclosures: M.M. Adil: None. A.E. Hassan: None. G.A. Vidal: None. A.A. Malik: None. F. Saeed: None. F. Khursheed: None. A.I. Qureshi: None.
- © 2015 by American Heart Association, Inc.