Abstract T P35: Extensive Cerebral Microbleeds Predict Parenchymal Hemorrhage and Poor Outcome After Intravenous Thrombolysis
Background and Purpose: Thrombolysis-related hemorrhagic transformation (HT) subtypes may have different prognostic implications. We aimed to analyze the impact of cerebral microbleeds (CMBs) burden on HT subtypes and outcome after intravenous thrombolysis.
Methods: We retrospectively examined clinical and radiological data from 300 consecutive acute ischemic stroke patients who underwent gradient-recalled echo (GRE) T2*-weighted MRI before intravenous thrombolysis. Logistic regression analysis was used to determine the impact of CMBs on HT subtypes and neurological outcome.
Results: Of the included patients, 101 (33.7%) were women, with a median age of 67 years (mean 66.12 ± 13.26 years, range 23-94 years). We observed 596 CMBs in 119 (39.7%) patients on initial GRE scans. HT occurred in 88 (29.3%) patients, among which 62 were hemorrhagic infarction and 26 were parenchymal hemorrhage (PH). Logistic regression analysis indicated that the presence of extensive (≥3) CMBs was independently associated with PH (odds ratio 6.704; 95% CI: 2.054 to 21.883; p = 0.002) and poor clinical outcome (odds ratio 2.281; 95% CI: 1.022 to 5.093; p = 0.044).
Conclusions: The presence of extensive (≥3) CMBs increased the risk of PH 24 hours after intravenous thrombolysis, and predicted poor clinical outcome independently.
Author Disclosures: S. Yan: None. M. Lou: None.
- © 2015 by American Heart Association, Inc.