Abstract T P367: Stable Childhood Stroke Rates Over 17 years: Report From a Population-Based Study
Background: We have published rates of childhood stroke using our population-based Greater Cincinnati Northern Kentucky Stroke Study for 1993/4 and 1999. We now report population-based rates from additional study periods of 2005 and 2010, and compare rates over time periods.
Methods: We identified all strokes in the Greater Cincinnati/Northern Kentucky (GCNK) region, a biracial population of 1.3 million, during 7/1/93 to 6/30/94 and calendar years 1999, 2005 and 2010. Stroke cases (both hemorrhagic and ischemic) were ascertained by screening for discharge ICD-9 codes 430 - 436 at all local hospitals, 437 - 438, 674 and 747 were also screened at the Children’s Hospital. Childhood stroke is defined as stroke in those <20 years of age at the time of onset. Incidence and overall stroke rates are estimated per 100,000, age-, sex- and race-adjusted to the 2000 US population.
Results: There were 14 strokes in children in 1993/4, 24 strokes in 1999, 15 strokes in 2005 and 17 strokes in 2010. Incidence rates by study period, overall, by race, sex and stroke type are reported in the table. We do not detect any significant change in the incidence rate over time. The overall (first ever or recurrent) stroke rate age-, sex- and race-adjusted to the 2000 US population under 20 years of age for the entire study period, is 4.4/100,000 (95% confidence interval: 3.4, 5.4),. Eleven children died within 30 days yielding an all-cause case fatality rate of 16%. Among all childhood stroke cases, 9 (13%) were identified at hospitals other than the Children’s Hospital.
Conclusions: The childhood stroke incidence rate of 4.1 per 100,000, in the GCNK study region has not changed significantly over 17 years Any study of pediatric stroke incidence should include screening of non-pediatric hospitals, as we found 13% of cases in adult hospitals.
Author Disclosures: J.C. Khoury: Research Grant; Significant; NIH NS 30678. S. Yeramaneni: None. J. Taylor: None. L. Lehman: None. H. Sucharew: Research Grant; Significant; NIH NS 30678. K. Alwell: Research Grant; Significant; NIH NS 30678. C.J. Moomaw: Research Grant; Significant; NIH NS 30678. K. Peariso: None. P. Khatri: None. J.P. Broderick: Research Grant; Modest; PRISMS Trial - Genentech. Honoraria; Modest; Boehringer Ingelheim. Consultant/Advisory Board; Modest; Pfizer. Other Research Support; Significant; Study medication for IMS III Trial Genentech. B.M. Kissela: Research Grant; Significant; NIH NS 30678. D.O. Kleindorfet: Research Grant; Significant; NIH NS 30678.
- © 2015 by American Heart Association, Inc.