Abstract T P418: The Association Of Cognitive Decline With Cerebral Microbleeds Appearance And Its Risk Factors: 9 Years Follow-up Study
Aims: Cumulative evidence indicates that the presence of cerebral microbleeds (CMB) is a highly strong risk factor for future brain hemorrhage. Our recent longitudinal study demonstrated the odds ratio of CMB for future brain hemorrhage was 50.2 (95% CI, 16.7 to 150.9). Since small vessel disease underlies CMB as a histopathological basis, the control of hypertension is supposed to be essential for preventing the occurrence of CMB. It remains unknown whether new appearance of CBM affects cognitive functions. We performed a longitudinal cohort study to clarify risk factors accounting for the appearance of CMB and its effects on cognitive functions.
Methods: In this study we followed up 97 healthy subjects (mean age 63 y.o. at the entry), who had undertaken brain MRI 9 years ago in our brain check-up system. No subjects had neurological symptoms at the first and second check-up. We assessed the changes of CMB in MRI and risk factors for the appearance or increase of asymptomatic lesions were examined. Cognitive function tests (a concise version of WAIS-R) were also performed at the entry and follow-up time. Age was used as a covariate in all statistics.
Results: During the 9-year follow-up period, we observed new appearance of CMB in 19 subjects (19.6 %: worsening group). The worsening group showed significantly higher values of systolic blood pressure at the time of entry compared to the no-change group (p=140) is 4.21 (p<0.05). In addition, the worsening group showed significant deterioration in cognitive function tests (p<0.05).
Conclusions: The present study demonstrates that the optimal control of blood pressure are critical for prevention of CMB appearance, which would contribute to prevention of future cognitive deterioration in addition to brain hemorrhage.
Author Disclosures: T. Nakagawa: None. K. Onoda: None. H. Takayoshi: None. S. Mitaki: None. H. Oguro: None. A. Nagai: None. S. Yamaguchi: None.
- © 2015 by American Heart Association, Inc.