Abstract T P51: MRI Characteristics of the Evolution of Lacunar Infarct Lesions
Background and Purpose: Morphological changes of lacunar infarct are not well defined. The purpose of the present study was to describe the MRI characteristics of the evolution of symptomatic lacunar infarcts. Methods: From a prospectively collected stroke database, 62 definite lacunar infarct patients with baseline and follow-up MRI (≥ 90 days of stroke onset) were analyzed. We investigated the incidence of cavitation, the infarct volume change, and the positional relationship between lacunar infarcts and preexisting white matter lesions (WMLs). Results: Median follow-up period was 26 months (range 3-99 months). Cavitation was observed in 38 patients (61%) and 25 lacunar infarct lesions (40%) overlapped with WMLs. Age, hypertension, baseline infarct diameter, baseline infarct volume, and baseline National Institute of Health Stroke (NIHSS) score were associated with cavitation (Figure). In a multiple logistic regression analysis, age (odds ratio per 5-year increase: 1.34; 95% confidence interval (CI): 1.03_1.80; p=0.03) and baseline infarct volume (odds ratio per 1-ml increase: 4.7; 95%CI: 1.6_19.7) were independent predictors of cavitation. There was a significant volume reduction between baseline and follow-up infarct lesions (median volume reduction rate: 44%, p<0.001). Conclusions: More than one third of symptomatic lacunar infarcts developed no cavitation and 40% of lacunar infarct lesions overlapped with WMLs. The incidence of cavitation strongly depended on the patient’s age and baseline infarct volume. Our data indicate the continuity between lacunar infarcts and WMLs.
Author Disclosures: S. Okazaki: None. E. Hornberger: None. M. Griebe: None. A. Gass: None. M.G. Hennerici: None. K. Szabo: None.
- © 2015 by American Heart Association, Inc.