Abstract W MP117: Intracarebral Hemorrhage Volume Growth and Lipid Lowering Agent use: Pooled Analysis of Interact Studies
Background and rationale: Despite several recent reviews of randomised trials, there remains controversy of the risks of intracerebral hemorrhage (ICH) associated with regular use of statins for prevention of cardiovascular disease, particular in populations with a high risk of ICH. We aimed to determine the risk of poor outcome and hematoma growth from use of lipid lowering agents among participants of the INTERACT substudies.
Design: Pooled analyses of INTERACT 1 and 2, international, multicenter, prospective, open, blinded endpoint, randomized controlled trials, of patients with ICH (<6 hr) and elevated systolic BP (SBP 150-180 mmHg). Associations between lipid lowering treatment and clinical outcomes (n=3184) were estimated in analyses of co-variance. Digital images from CT substudies participants (n=1310) underwent blinded central analyses comparing measurements from standardized baseline and 24 hrs CTs. Associations between lipid lowering treatment and hematoma volume growth from baseline to 24 hrs were estimated in analyses of co-variance.
Results: Among 204 patients (9%) with lipid lowering treatment at ICH onset, both death and dependency were higher after 90 days, but this was not significant with multivariable adjustment for baseline imbalances and confounding factors (p=0.783). In analysis of CT substudies, absolute ICH volume was larger among 124 patients (9%) with lipid lowering therapy compared to patients without prior therapy but again, multivariate-adjustment made this difference non-significant (9.2ml vs 6.8ml, p=0.13), with antithrombotic use being the main confounder.
Conclusion: In the INTERACT studies, there was no association between lipid lowering use and adverse clinical outcomes.
Author Disclosures: M.L. Priglinger: None. H. Arima: None. C. Anderson: Speakers' Bureau; Modest; Takeda China, Covidien. Consultant/Advisory Board; Modest; Pfizer, The Medicines Company. Research Grant; Significant; National Health and Medical Research Council (NHMRC) of Australia. M. Krause: None.
- © 2015 by American Heart Association, Inc.