Abstract W P159: Impact of Body Mass Index on 1-year Outcome After Acute Ischemic Stroke
Introduction: Debates exist in the impact of overweight and obesity on the outcome after stroke. Our study is aimed to investigate the relation between body mass index(BMI) and stroke outcome in a broad range of hospitalized patients with acute ischemic stroke in China.
Methods: Data are from the ChinaQUEST (QUality Evaluation of Stroke Care and Treatment) study, a multi-centre, prospective, 62-hospital registry in China during 2006-07. Patients were categorized as underweight(BMI<18.5), normal(BMI 18.5 to <25), overweight(BMI 25 to <30) and obesity(BMI≥30). The primary endpoint was all-cause mortality at 12 months. The secondary endpoint was the proportion of death or dependency (modified Rankin Scale score 3-5) at 12 months.
Results: There were 4782 patients with acute ischemic stroke enrolled in ChinaQUEST registry study. According to BMI, 282(5.9%) patients were of underweight, 2889(60.4%) were of normal weight, 1408(29.4%) were of overweight, and 203(4.2%) were obese. Outcome measures at 12 months were available in 4645 patients. The mortality was 21.3%(58/272) for underweight group, 10.6%(299/2810) for normal weight group, 8.5%(116/1365) for overweight group and 9.1%(18/198) for obesity group. The corresponding proportion of death or dependency was 45.6%(124/272), 30.9%(867/2810), 28.1%(384/1365) and 29.3%(58/198), respectively. After adjustment for all confounders, compared with patients of normal weight, odds ratio(95% confidence interval) of death at 12 months was 1.985(1.373-2.868) for underweight group, 0.952(0.738-1.229) for overweight group and 0.844(0.468-1.522) for obesity group. The corresponding odds ratio(95% confidence interval) of death or dependency at 12 months was 1.541(1.155-2.054), 1.004(0.853-1.181) and 0.837(0.578-1.211), respectively.
Conclusion: In ischemic stroke patients, a J-shaped relationship between BMI and stroke outcome was observed. Underweight was associated with the highest risk for unfavorable outcome. No benefit of overweight and obesity on the survival or functional outcome over normal weight was found.
Author Disclosures: W. Sun: None. S. Zhu: None. R. Liu: None. F. Li: None. W. Sun: None. Y. Huang: None.
- © 2015 by American Heart Association, Inc.