Abstract W P23: A Multi-Center Assessment on the Effect of Using Eptifibatide Drip During Endovascular Procedures on the Functional Outcome of Patients Presenting with Acute Ischemic Stroke
Background: Endovascular procedures are associated with injuries to the vasculature. Interventionists have adopted the use of intravenous anti-platelet agents. Eptifibatide drip has been utilized in advanced stroke treatment to increase recanalization in ischemic strokes. This study compares the outcome and mortality between those individuals that received Eptifibatide drip and those who did not.
Materials: This is a retrospective analysis of all patients (n= 161) who presented to the hospitals with ischemic stroke and considered for advanced stroke therapy between January 2009 and July 2014. Statistical analysis was performed using GraphPad Prism. We divided the groups into two: (A) Eptifibatide drip (B) No Eptifibatide drip. We compared the effect of using Eptifibatide drip on the functional outcome using modified Rankin Scale (mRS). mRS score of 2 or less defines a good functional outcome and an mRS of 6 defines mortality. All variables were included in the analysis.
Results: 161 patients included in this study had all the variables and received Endovascular treatment. Group analysis including n, gender, mean age, mean NIHSS, Afib%, DM% and Prior Stroke % was as follows: A) 66, 47%, 71.6±16.7, 16.0±7.1, 28.3%, 25% and 31.7% B) 95, 62.5% female, 74.5±16.3, 16.5±7.7, 44.2%, 30.5% and 23.2%. We found that patients who underwent endovascular procedures in group A experienced a better outcome and lower mortality as compared to those patients in group B (95% CI, 0.1761-0.3953, P<0.001); (95% CI,-0.4761- -0.2569, P<0.001).
Conclusion: The use of Eptifibatide drip during endovascular procedures may result in a better functional outcome and lower mortality after the procedures as compared to other devices. We plan to further investigate the use of Eptifibatide drip in prospective study.
Author Disclosures: H. Dababneh: None. S. Sakian: None. H. Zheng: None. R. Kumar: None. S. Azhar: None. K. Arcot: None. A. Bashir: None. M. Hussain: None. J. Farkas: None. A. Tiwari: None.
- © 2015 by American Heart Association, Inc.