Abstract W P309: Serum Albumin Predicts Outcome In Primary Intracerebral Hemorrhage
Background&Purpose: Low serum albumin is associated with poor outcomes in ischemic stroke. Albumin levels are a marker of nutritional status; albumin also has neuro-protective effects. The role of serum albumin in outcomes in patients with ICH has not been investigated. We examined the association between initial admission albumin and functional outcome at discharge.
Subjects&Methods: Consecutive patients (2008 - 2013) diagnosed with primary ICH at our academic stroke center in the Southeast US were retrospectively analyzed. Demographics, initial lab values, and ICH scores were recorded. A poor outcome was defined as mRS 4-6 at discharge. Eligible patients were divided into two groups based on ICH score (0-2 and 3-6). Statistical significance was determined using logistic regression.
Results: A total of 103 patients met inclusion criteria (mean age 63, 45% women, 49% black). In patients with an ICH score of 0-2 (n=85), higher albumin was associated with lower odds of poor functional outcome at discharge (OR=0.40, 0.18 - 0.89; p=0.026). For every 1g/dL increase in albumin, the odds of poor outcome were reduced by 60%. This relationship was not observed in patients with an ICH score of 3-6 (n=18, OR=2.41, 0.06 - 99.5; NS).
Conclusions: Serum albumin on admission predicts outcome at discharge. Patients with low ICH severity seem to be most sensitive to lower serum albumin levels. Early nutritional support may translate into better clinical outcomes in ICH patients. Future studies incorporating other measures of nutritional status are needed to better delineate optimal serum albumin levels and to understand this effect.
Author Disclosures: H. Shiue: None. K.C. Albright: None. K.A. Sands: None. A.N. Hays: None. A. Gadpaille: None. A. Khawaja: None. A. Sisson: None. M. Alvi: None. R. Shahripour: None. M. Harrigan: None.
- © 2015 by American Heart Association, Inc.