Abstract W P324: The Influence Of Low Density Lipoprotein On Intracerebral Hemorrhage Volume
Background and Purpose: High dose statin use either before (pre-morbid) or after an acute ischemic stroke has been associated with an increased risk of ICH. Prior studies suggest that premorbid statin use has a beneficial effect whereas lower LDL levels have a detrimental effect on functional outcomes in primary ICH. We sought to evaluate if pre-morbid statin use and serum LDL levels impacted ICH volume and outcomes in ICH.
Methods: Patients with ICH admitted to our center from 2008-2013 were included. Demographic and clinical data were collected. Primary outcomes of interest were a large volume ICH (defined as volume greater than or equal to 30cc), and poor functional outcome at discharge defined as mRS of 4-6. Crude and adjusted logistic regression models were used to assess the relationship between LDL, statins and outcomes.
Results: Of 403 patients, 18.6% (n=75) were taking a statin prior to ICH onset. The odds of a large volume ICH decreased by 12% for each 10 point decrease in serum LDL (OR 0.888, 95%CI 0.81-0.97, p=0.0115). In statin-naïve patients, the odds of a large volume ICH decreased by 16% for each 10 point decrease in LDL value (OR 0.84, 95%CI 0.76-0.94, p=0.0019). Patients who were on a statin prior to their ICH had no association between large volume ICH and LDL (OR 1.07, 95%CI 0.88-1.32, p=0.49). Statin use prior to ICH had no significant association with volume and location of ICH, admission NIHSS and a discharge mRS of 4-6 compared to statin-naïve patients (see Table).
Conclusions: Statin use prior to ICH onset had no significant association with ICH volume or location, admission NIHSS, or poor short-term functional outcomes in comparison to statin-naïve patients. Lower serum LDL values were significantly associated with a decreased odds of large volume ICH, with the effect being driven by statin-naïve patients.
Author Disclosures: A. Khawaja: None. A.K. Boehme: None. K. Kicielinski: None. K. Arora: None. M. Lyerly: None. M. Alvi: None. G. Kumar: None. M. Harrigan: None.
- © 2015 by American Heart Association, Inc.