Abstract W P378: Cerebrovascular Risk Factors and Carotid Plaque Stability: a Community Cross-Sectional Study in Chinese Stroke High-Risk Population
Introduction: Previous carotid ultrasound studies have found that carotid plaques with low echogenicity which suggest poor stability had a higher risk of cerebrovascular events. Studies to investigate the relationship between carotid plaques stability and cerebrovascular risk factors in stroke high-risk population are rare. The aim of the present study is to examine the relationship between cerebrovascular risk factors and carotid plaques stability in stroke high-risk population in China.
Methods: A community cross-sectional study was conducted from 2012 to 2013. A cluster random sample of 2558 Chinese participants aged 40 years or older was enrolled. The risk factors for cerebrovascular disease were assessed. Carotid plaque stability was conducted by high-resolution color Doppler ultrasound. Logistic regression model was used to analyze the association between cerebrovascular risk factors and carotid plaque stability.
Results: Hypertension (odds ratio = 1.513; 95% confidence interval = 1.176-1.946), smoking (OR = 173.788; 95% confidence interval = 86.495-349.180), hyperlipidemia (OR = 1.566; 95% confidence interval = 1.245-1.969), diabetes mellitus (OR = 1.274; 95% confidence interval = 1.037-1.566) and hyperhomocysteinemia(OR = 1.009; 95% confidence interval = 1.000-1.017) are independently associated with development of carotid plaques. However, only triglyceride level (OR = 1.177; 95% confidence interval = 1.046-1.323) is an independent risk factor for carotid plaque stability.
Conclusion: In subjects from the Chinese stroke high-risk population with unstable plaques, This founding suggest that triglyceride level may be associated with unstable carotid plaques, rather than other risk factors.
Author Disclosures: L. He: None. F. Qin: None. N. Chen: None.
- © 2015 by American Heart Association, Inc.