Abstract W P393: Postural-related Cerebral Hemodynamic Responses Assessed by Near Infrared Spectroscopy in Patients with Chronic Cerebral Infarction
Introduction: Near infrared spectroscopy (NIRS) is a non-invasive optical technique to monitor dynamic cerebral tissue blood volume. Although previous studies have implied cerebral blood volume changed slightly during acute orthostatic stress, the impact of chronic cerebral infarction (CI) on the cerebral hemodynamic response during postural change was unclear.
Hypothesis: We hypothesized that chronic CI was independently associated with decreasing cerebral blood flow (CBF) during active orthostatic stress.
Methods: We designed a cross sectional study to investigate the relation between chronic CI and the postural-related changes of CBF. A total of 100 subjects with or without chronic CI were enrolled in this study. Postural-related changes of average bilateral frontal cortical CBF were non-invasively and continuously measured by using NIRS (NIRO 100, Hamamatsu Photonics, Shizuoka, Japan) during orthostatic stress.
Results: The proportion of decreasing CBF during active orthostatic stress was higher in patients with chronic CI than in those without chronic CI (76.3% and 30.6%, respectively, p<0.001). The changes in CBF during active orthostatic stress in patients with chronic CI were significantly lower than those in participants without chronic CI (-4.5±7.4% and 1.7±4.1%, respectively, p<0.001) In unadjusted model, the odds ratio (OR) (95% confidence interval) for decreasing CBF during active orthostatic stress in patients with chronic CI was 3.22 (1.52-6.81, p=0.002). After adjusted covariates, a multiple logistic-regression analysis revealed that the adjusted OR (95%CI) was 5.23 (1.68-16.32, p=0.004).
Conclusion: Chronic CI was an independent risk factor for decreasing CBF during active orthostatic stress.
Author Disclosures: H. Irisawa: Research Grant; Modest; JSPS KAKENHI Grant No. 23650320. K. Odagiri: None. N. Katayama: None. T. Mizushima: None. H. Watanabe: None.
- © 2015 by American Heart Association, Inc.