Abstract W P424: Poor Functional Outcome And Intracerebral Hemorrhage: What Are The Main Factors?
Background: Although variables associated with mortality in patients with intracerebral hemorrhage (ICH) are well known, there are few data about which factors are related to functional prognosis in these patients. Therefore, the aim of our study was to study the factors that determine poor functional outcome at three months in patients with ICH.
Material and methods: We prospectively studied 241 patients consecutively admitted to our stroke unit due to a primary ICH within 12 hours of symptom onset. Clinical, radiological, and analytical data during hospitalisation were collected. Patients were also evaluated at three months. We defined as good outcome if modified Rankin scale (mRS) at three months was ≤2 and bad outcome if mRS was between 3 and 5.
Results: At three months, 36.1% of patients presented good outcome (group A), 38.2% of patients poor outcome (group B) and 25.7% had died (85.5% of them during hospitalization). Patients of group B were significantly older (67 years vs 63), had a higher NIHSS at admission (15 vs 6), greater basal hematoma volume (23.8 cc vs 6.2 cc) and basal edema volume (10.9 cc vs 3.2 cc), a higher proportion of women (31.4% vs 14.9%), early neurological deterioration (END) (19.8% vs 3.4%), lobar localization of the hematoma (18.6% vs 11.4%), frontal lobe impairment (34.9% vs 9.1%) and insular ribbon (30.2% vs 6.8%), higher mass effect (26.9% vs 16.9%), relevant hematoma growth at 24 hours (78.4% vs 50%) and a greater frequency of more than 2 spot sings on neuroimage (47.8% vs 12.9%).
In the logistic regression analysis, baseline NIHSS, END, lobar localization of the hematoma, frontal lobe and insular ribbon impairment, the presence of mass effect, hematoma and edema volume on baseline CT and a number of spot signs > 2 were significantly associated with poor outcome of patients.
Conclusions: New radiological variables have to be considered for predicting poor outcome in patients with intracerebral hemorrhage in addition to classical factors.
Author Disclosures: M. Terceño: None. Y. Silva: None. J. Serena: None. C. van Eendenburg: None. G. Blasco: None. J. Puig: None. M. Castellanos: None.
- © 2015 by American Heart Association, Inc.