Stroke Literature Synopses: Clinical Science
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Amarenco P, Lavallee PC, Labreuche J, Albers GW, Bornstein NM, Canhao P, et al. One-year risk of stroke after transient ischemic attack or minor stroke. N Engl J Med. 2016;374:1533–1542. doi: 10.1056/NEJMoa1412981.
Using data from the TIAregistry.org project, Amarenco et al described the risk of stroke, acute coronary syndrome, or death from cardiovascular causes among individuals with transient ischemic attack or minor stroke who received urgent evaluation (<7 days) by a stroke specialist.
From 2009 to 2011, 4789 patients at 61 sites in 21 countries were enrolled, of whom 78% were evaluated by a stroke specialist <24 hours after symptom onset. On initial evaluation, 33.4% of the patients had an acute stroke, 15.5% had ≥1 extracranial or intracranial arterial stenosis ≥50%, and 10.4% had atrial fibrillation. Nearly one third (26.9%) of those with carotid stenosis underwent revascularization. With a median follow-up of 27.2 months (interquartile range, 12.4–48.1), risk of recurrent stroke at 2, 7, 30, 90, and 365 days were 1.5%, 2.1%, 2.8%, 3.7%, and 5.1%. One-year risk of composite cardiovascular events …