Response by Chen et al to Letter Regarding Article, “Endovascular Hypothermia in Acute Ischemic Stroke: A Pilot Study of Selective Intra-Arterial Cold Saline Infusion”
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We are thankful to Mattingly et al for their interest and critical evaluation of our article. In comparison to other studies, we did not measure the temperature of brain tissue directly because we considered the risk of intracranial hemorrhage in patients with acute ischemia who usually received antithrombotic treatment. Several theoretical models demonstrated that an infusion of ice-cold saline at ≈30 mL/min through the internal carotid artery is sufficient to induce moderate hypothermia in the human brain within 10 minutes.1,2 Another study by Choi et al3 showed that …