Response by Chen et al to Letter Regarding Article, “Magnetic Resonance Imaging of Plaque Morphology, Burden, and Distribution in Patients With Symptomatic Middle Cerebral Artery Stenosis”
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We appreciate the opportunity to respond to comments by Du et al about our recent article,1 which was a hospital-based pilot study using high-resolution magnetic resonance imaging (HRMRI) to investigate the total intracranial plaque burden in patients with symptomatic middle cerebral artery stenosis. HRMRI is a promising imaging modality to visualize intracranial arterial wall pathology, yet to be validated for interpreting the clinical significance of signal changes.
Du et al suggest that quantitative MRI measurements should be performed. We agree that morphological measurements of intracranial vessels are feasible, but not compulsory for every study involving HRMRI technology. The ultimate purpose of HRMRI study is to identify proper imaging biomarker for predicting clinical outcome rather than for …