Letter by de Boysson and Pagnoux Regarding Article, “Diagnostic Yield and Safety of Brain Biopsy for Suspected Primary Central Nervous System Angiitis”
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To the Editor:
We read with interest the recent study by Torres et al1 on the diagnostic value and risks of brain biopsy in patients with suspected primary angiitis of the central nervous system (PACNS). Brain biopsy revealed PACNS in 11% of patients and showed perivascular infiltrate in 18% and alternative diagnoses in 30%. No baseline clinical, surgical, or imaging characteristics predicted a positive biopsy. Postbiopsy complications affected 16% of patients.
Findings from the other rare cohorts of PACNS patients not only are somewhat in agreement but also add some complimentary information, which we think could be of interest to readers.2,3 In our previous report on the first …