Letter by Chen et al Regarding Article, “Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial”
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To the Editor:
With great interest and appreciation, we have read the article by Di Tullio et al1 titled “Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial.” The study revealed that left ventricular ejection fraction (LVEF) is inversely associated with death and its components, ischemic stroke, and HF hospitalization in patients with heart failure (HF) and reduced ejection fraction (HFrEF) in sinus rhythm (SR). Increased stroke risk is associated with low LVEF values, and an interaction with warfarin treatment on stroke risk may exist.
WARCEF trial (Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction) is the most …