Response to Letter Regarding Article, “Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke”
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Matrix metalloprotease 3 (MMP3) is a zinc endopeptidase that has the ability to digest and degrade the basal lamina and tight junction proteins causing increased blood–brain barrier disruption.1 We showed that acute hyperglycemia increased MMP3 activity in the brain after stroke and this was associated with exacerbated cerebral hemorrhage and worse functional outcomes. Both pharmacological and molecular inhibition of MMP3 reduced the injury and improved the outcomes.
It was previously shown that MMP3 plays …