Letter by Nielsen et al Regarding Article, “Ischemic Stroke Risk in Patients With Atrial Fibrillation and CHA2DS2-VASc Score of 1: Systematic Review and Meta-Analysis”
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To the Editor:
We read with great interest the Brief Report by Joundi et al.1 Using contemporary data from observational studies investigating stroke rates in nonanticoagulated populations, the authors clearly demonstrated that atrial fibrillation (AF) patients with a CHA2DS2-VASc score of 1 are candidates for oral anticoagulation (OAC). The authors should be commended by their efforts for meticulousness in study selection and the accuracy in reporting meta-analyzed results using state-of-art methodology.
Indeed, the methodological considerations are pivotal when designing observational studies investigating stroke rates in an untreated AF population similar to the studies included in the present meta-analysis. Much effort has recently been focusing on whether AF patients with a CHA2DS2 …