Letter by Guo et al Regarding Article, “Lymphocytopenia Is an Independent Predictor of Unfavorable Functional Outcome in Spontaneous Intracerebral Hemorrhage”
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To the Editor:
We read with great interest the study by Giede-Jeppe et al,1 which provided evidence that lymphocytopenia is an independent predictor of unfavorable functional outcome in spontaneous intracerebral hemorrhage (ICH). We would like to highlight 3 important issues raised in the study by Giede-Jeppe et al.1
First, why does the number of circulating lymphocytes decrease in patients with ICH? Two major reasons come to mind: one has to do with the severity and progression of ICH, and the second reason is related to some external environment factors, such as infections that can potentially change lymphocytes. If lymphocytopenia is related to the severity of disease process, then …