Letter by Iannuccelli et al Regarding Article, “Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke”
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To the Editor:
We read with a great interest the recent article published in Stroke by Gonzalez-Valcarcel et al1 on the association between paracetamol and ibuprofen use with major cardiovascular events or major bleeding in patients. The authors accomplished a huge task analyzing a cohort of 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin. They observed that patients who used paracetamol daily have a higher risk of major cardiovascular events; patients who used ibuprofen seems not to have a significant increase in the risk of major cardiovascular events, but the results become consistent when …