Abstract 93: MR Black-Blood Thrombus Imaging (BTI) for the Early Detection and Quantification of Cerebral Venous Thrombosis
Introduction: Cerebral venous thrombosis (CVT) is an unusual but important cause of stroke mainly affecting young individuals. Accurate diagnostic assessment of potential CVT is a major clinical challenge because the positive findings of intraluminal thrombus are not always evident. The purpose of this study was to prospectively evaluate the diagnostic performance of a novel MR black-blood thrombus imaging(BTI)technique in patients with suspected CVT.
Methods: A total of 58 consecutive patients who were suspected of CVT were prospectively enrolled for the BTI study. The clinical diagnosis based on conventional imaging techniques was used as the reference standard. Diagnostic performance of BTI on both per-segment and per-patient basis were analyzed. Informed consent was obtained from all participants, and all protocols were approved by the Institutional Review Board.
Results: BTI was successfully performed in all 58 patients without complications. BTI correctly identified CVT in 36 patients and correctly ruled out CVT in 20 patients. The sensitivity and specificity of BTI for detecting CVT were 95.6% (152 of 159), 98.0% (653 of 640), and 84.1% (657 of 781), respectively, on a per-segment basis. These values were 97.3% (36 of 37) and 95.2% (20 of 21), respectively, on a per-patient basis. Figure 1 demonstrates detection and volume quantification of thrombus in the superior sagittal sinus, the right transverse and sigmoid sinuses, and the cortical veins.
Conclusion: BTI allows for selective visualization of thrombus with high sensitivity and high specificity. The current findings support that BTI can be used as a promising first line diagnostic imaging tool.
Author Disclosures: Q. Yang: None. Z. Fan: None. J. Duan: None. X. Ji: None. K. Li: None. D. Li: None.
- © 2016 by American Heart Association, Inc.