Abstract WP190: Clinical Features of Sarcoid Patients With Ischemic Stroke
Background: Current knowledge on ischemic stroke in sarcoid patients stems from sporadic case reports. The mechanism is thought to be related to granulomatous involvement of brain vasculature. However, clinical, demographic, and radiographic features of sarcoid patients with ischemic stroke are lacking. If sarcoid patients are at higher risk for ischemic stroke event, we hypothesized that the risk factors for ischemic stroke and stroke subtype distribution would differ between sarcoid and non-sarcoid ischemic stroke patients.
Methods: Cases of ischemic stroke were identified for the years 2005 and 2010 from the population-based Greater Cincinnati/Northern Kentucky Stroke Study (population 1.3 million). Ischemic stroke cases were physician study confirmed and patients with a history of sarcoid were identified through medical chart review. Clinical variables were compared between stroke patients with history of sarcoid and those with no prior sarcoid history.
Results: A total of 4258 cases of ischemic stroke were identified; of them, only 18 had prior diagnosis of sarcoid (0.04%). Brain MRI showed diffusion restriction in 14 out of 15 (93%) MRIs performed in sarcoid patients. The table presents risk factor and subtype data on sarcoid patients compared with non-sarcoid patients.
Conclusions: We identified only a few cases of prior sarcoid history in our two-year ascertainment of ischemic stroke patients in our population. In comparison with stroke patients with no prior history of sarcoid, the sarcoid patients tended to be of younger age at presentation, female, have a history of diabetes and hyperlipidemia, and more likely of African descent, perhaps related to the diagnosis of sarcoid itself. We were unable to detect differences in stroke subtype distributions between sarcoid and non-sarcoid ischemic stroke patients.
Author Disclosures: A.Z. Obeidat: None. H. Sucharew: Research Grant; Significant; R01NS30678. C.J. Moomaw: Research Grant; Significant; R01NS30678. D.O. Kleindorfer: Speakers' Bureau; Modest; Genentech. Research Grant; Significant; R01NS30678. B.M. Kissela: Research Grant; Significant; R01NS30678. K. Alwell: Research Grant; Significant; R01NS30678. M. Flaherty: Research Grant; Modest; R01NS30678. J.P. Broderick: None. D. Woo: Research Grant; Modest; R01NS30678.
- © 2016 by American Heart Association, Inc.