Abstract WP361: Patients From the Tranexamic Acid for Hyperacute Intracerebral Haemorrhage (TICH-2) Trial Suffering From Hyperglycaemia at Baseline; Their Characteristics and Day 90 Outcomes
Introduction: Hyperglycaemia (HG) at presentation has been associated with poor outcome in intracerebral haemorrhage. Relationship with haematoma location (HL) has not been studied.
Methods: In the ongoing TICH-2 study, history of diabetes and blood glucose level is recorded at baseline. Baseline characteristics and day 90 outcomes were compared for those with HG (glucose>6.5 mmol/L) and people with a history of diabetes. Day 90 outcomes include; modified Rankin Scale (mRS), Barthel index (BI) and Euroqol-5D (EQ-5D).
Results: As of 21st July 2015, of 1065 participants, 477 (44.8%) of these had HG. Patients with HG had more lobar and infra-tentorial, than deep locations (chi-square: p<0.0001) and their baseline NIHSS scores were worse (multiple linear regression (MLR): p<0.0001). Day 90 mRS was worse for the HG patients (ordinal logistic regression, OR (95% CI): 1.87 (1.47, 2.38), p<0.0001). MLR was performed on other day 90 outcomes; BI (p=0.0103), EQ-5D (p<0.0001) and Zung (p=0.0447) were all worse for the HG group. The total number of patients with a SAE was found to differ significantly (chi-square: p<0.0001). Deaths were analysed and found to be non-significant. Patients with a history of diabetes were found to have significantly higher baseline glucose levels than those without (9.8 vs. 6.7, MLR: p<0.0001). BI was the only significant outcome for patients with diabetes (p=0.0473).
Conclusion: Participants with HG had different haematoma locations and a worse NIHSS score at baseline. They also had significantly worse outcomes at day 90. History of diabetes was related to glucose level and BI at day 90 but not HL or other outcomes.
Author Disclosures: N. Sprigg: None. K. Robson: None. P.M. Bath: None.
- © 2016 by American Heart Association, Inc.