Abstract WP393: Cervical Arterial Fibromuscular Dysplasia in a Bi-ethnic Population: a Retrospective Study in U.S.-Mexican Border
Background: There have been studies trying to characterize Fibromuscular Dysplasia (FMD), however most of them are based in mainly non-Hispanic samples. The objective of this study is to describe the epidemiology, clinical characteristics, angiographic findings, and associated vascular conditions of cervical arterial fibromuscular dysplasia in Hispanics in the US-Mexican border.
Methods: We retrospectively reviewed the cerebral angiograms performed in our center in a period of 3.5 years under different indications (cervical and intracranial steno-occlusive arterial disease, intracranial vascular malformation, cranial and facial tumor embolization, and subarachnoid hemorrhage) looking for angiographic patterns of FMD involving the cervical (internal carotid and vertebral) arteries. Exclusion criteria included subjects younger than 18 years old. Patients were subdivided by their self-reported ethnicity in Hispanics and non Hispanics. Of those patients found to have FMD, we looked for the association with the demographics, co-morbidities and related supra-aortic vascular abnormalities.
Results: We analyzed 467 angiograms among patients >18 years of 323 (69.1%) were Hispanics and 144 (30.8%) were non-Hispanics. We found that 27 (8.3%) Hispanics patients with FMD involving the cervical arteries (internal carotid, vertebral artery isolated and in different combinations), while 20 (13.8%) cases of FMD among the non-Hispanics. There was no significant difference between the two groups regarding the frequency of FMD. In the Hispanic FMD group the mean age was 57.5 ± 15.76 years and 77.7% were females (p-value=0.007). The most common intracranial and cervical arterial conditions associated with FMD in the Hispanic group were aneurysms and arterial dissections that account for 60% and 25.9% respectively. There was a significant association between Hispanic with Female FMD and intracranial aneurysm (p=0.03).
Conclusion: Our study suggests that FMD might follow the same demographic and clinical characteristics in Hispanics and non Hispanic populations in North-America. FMD in Hispanics has a clear predilection for women and intracranial aneurysm and supra-aortic arterial dissection are most commonly associated conditions.
Author Disclosures: I.A. Qureshi: None. A. Maud: None. T. Chacon: None. S. Cruz-Flores: None. G. J Rodriguez: None.
- © 2016 by American Heart Association, Inc.