Stroke Literature Synopses: Basic Science
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Cerebral white matter is vulnerable to ischemic insults, and aging is a major risk factor to exacerbate white matter damage in stroke. Three recent studies provide insights into potential therapeutic approaches that may be used to ameliorate age-related white matter responses after stroke.
Sozmen et al (Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice. Proc Natl Acad Sci USA. 2016;113:E8453–E8462. doi: 10.1073/pnas.1615322113) investigated the roles of Nogo/NgR1 signaling in remyelination after white matter stroke. This study used a mouse model of white matter stroke by injecting L-Nio into the corpus callosum region. L-Nio is a nonselective inhibitor of all nitric oxide synthase isoforms, and L-Nio injection induces focal ischemia by vasoconstriction. With this model, the authors first demonstrated that oligodendrocyte precursor cells proliferated in the damaged white matter region. However, those oligodendrocyte precursor cells failed to mature into oligodendrocytes but instead differentiated toward astrocytes. …