Response by Sposato et al to Letter Regarding Article, “Effect of Right Insular Involvement on Death and Functional Outcome After Acute Ischemic Stroke in the IST-3 Trial (Third International Stroke Trial)”
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We appreciate Alves et al for their comments on our article, Effect of Right Insular Involvement on Death and Functional Outcome After Acute Ischemic Stroke in the IST-3 Trial.1
Insular involvement after ischemic stroke has been associated with worse outcomes. However, until recently, results were conflicting because most studies failed to adjust their analyses for variables known to impact on stroke death and functional outcome such as stroke severity or the volume of infarcted brain tissue.2 Furthermore, the role of laterality has been rarely addressed. We showed an association between right insular involvement and higher odds of death and worse functional outcome at 6 months after adjustment for age, stroke severity, lesion size, atrial fibrillation, treatment with intravenous recombinant …