Response by Wang and Johnston to Letter Regarding Article, “Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)”
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We appreciate the comments and suggestions by Moris et al about our article.1 We would like to add some clarification.
As noted by Moris et al, 26.5% of Asian patients in this trial were using aspirin before randomization. Although no significant interaction was observed, the sample size of the Asian subgroup was small and there was a trend of greater effect of ticagrelor in patients with previous aspirin use. This could be evidence of aspirin failure, as suggested by Moris et al, but it could also be explained by residual antiplatelet …