Letter by Nabavizadeh et al Regarding Article, “Prediction of Blood–Brain Barrier Disruption and Intracerebral Hemorrhagic Infarction Using Arterial Spin-Labeling Magnetic Resonance Imaging”
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
To the Editor:
The study by Niibo et al1 showed that detecting hyperemic lesions (HLs) using arterial spin-labeling (ASL) imaging is a reliable method to predict and localize subsequent blood–brain barrier disruption and hemorrhagic transformation. With great interest, we have some concerns about the methodology of the study.
In the methodology, an HL was defined “as a visually perceivable increase in the CBF [cerebral blood flow] on ASL maps either within or around the hypoperfused lesion. HLs had to be clearly distinct from vascular structures.” Subsequently, the authors used a region of interest of the HL on ASL maps to calculate the quantitative cerebral blood flow values in HLs. The authors did not describe how they could confidently differentiate HLs especially the ones …