Letter by Venema et al Regarding Article, “Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke”
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To the Editor:
We read the study by Bivard et al,1 in which they develop a model that predicts functional outcome in patients with acute ischemic stroke based on clinical and advanced imaging characteristics, with great interest. Prognostic modeling for acute ischemic stroke is a very relevant topic and may be useful in identifying individual patients with no or little benefit from reperfusion therapy. Unfortunately, we noted several methodological shortcomings in the model development and validation. We will discuss some of these and propose recommendations for future prediction studies in stroke research.
One of the first steps in prediction modeling is the coding of predictors. Bivard et al1 have dichotomized the continuous predictors (age, baseline National Institutes …