Response by Bivard et al to Letter Regarding Article, “Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke”
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We thank Venema et al for their continuing attention1 to our recent work.2 Careful reading of the Statistical Methods section would have identified that our analysis did not dichotomize variables for a regression model, but rather used the output of the classification and regression tree analysis. As Venema et al will be aware, the classification and regression tree analysis output is dichotomous and indeed clinically meaningful, aligning in the 4.5-hour alteplase time …