Letter by Kawada Regarding Article, “Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study”
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To the Editor:
Golsari et al1 evaluated the risk factors of silent brain infarctions and leukoaraiosis in 112 patients with acute retinal ischemia. A total of 77 (68.8%) had retinal arterial occlusion, and 17 (15.1%) had silent brain infarctions. By binary logistic regression analysis, internal carotid artery stenosis was significantly associated with silent brain infarctions with odds ratio (95% confidence interval) of 4.27 (1.06–17.23). I have some concerns about their study.
First, the authors used 8 independent variables simultaneously for conducting logistic regression analysis. The number of events …