Response by Golsari and Thomalla to Letter Regarding Article, “Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study”
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We thank Dr Kawada for making important comments on our study. We fully agree with the notion that because of the small number of cases, the multivariate analysis has limitations. To date, there have been no larger prospective studies systematically investigating the occurrence of silent brain infarctions in patients with retinal ischemia in terms of pathogenesis and contributing factors. The results of our study thus have to be considered exploratory and await confirmation in future studies. However, the silent brain infarctions observed in our sample of patients with retinal ischemia were mostly small embolic cortical and subcortical lesions in the internal carotid artery (ICA) territory, and the association of silent brain infarctions with the presence of ipsilateral stenosis of the ICA was strong and is biologically plausible. This observation confirms …