Response by Pase et al to Letter Regarding Article, “Sweetened Beverages and the Risks of Incident Stroke and Dementia”
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We thank Dr Fenton and Dr Bellman for their letter regarding our recent article concerning sugar and artificially sweetened beverage (ASB) consumption and the risks of stroke and dementia.1 There are 2 main issues raised by Fenton and Bellman. The first relates to our examination of mediation, and the second relates to the fact that we did not adjust for multiple comparisons. We address each point in turn.
After mediation analysis, we examined the associations between ASB intake and both all dementia and Alzheimer disease dementia after excluding persons with prevalent diabetes mellitus, as well as the association between ASB intake and stroke after excluding subjects with prevalent hypertension. Although we adjusted …