Response by Brinjikji et al to Letter Regarding Article, “Anesthesia-Related Outcomes for Stroke Revascularization: A Systematic Review and Meta-Analysis”
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We would like to thank the SAGA (SIESTA-AnSTroke-GOLIATH-Association) investigators for their letter regarding our recently published article titled “Anesthesia-Related Outcomes for Stroke Revascularization: A Systematic Review and Meta-analysis.”1
Overall, we agree wholeheartedly with the notion that there are substantial limitations to the current literature. Retrospective studies and post hoc analyses of randomized controlled trials are prone to substantial selection bias. Furthermore, marked heterogeneity in definition of general anesthesia as well as devices and techniques use during thrombectomy (pre- versus poststent retriever era) further cloud inferences. For these reasons, we performed meta-regression analyses adjusting for baseline National Institutes of Health Stroke Scale as well as sensitivity analyses, including studies from …