Letter by Guo et al Regarding Article, “Prevalence and Natural History of Superficial Siderosis: A Population-Based Study”
To the Editor:
Cortical superficial siderosis (cSS) and cerebral microbleeds (CMBs) are important risk factors for intracerebral hemorrhage (ICH) along with a lack of understanding of the mechanism by which cSS and CMBs lead to increased future ICH risk. APOE (apolipoprotein E) ε2 genotype might have different pathophysiological mechanisms between cSS and CMBs in ICH.1 We read with interest the recent article by Michael et al,2 investigating the prevalence of cSS and the association between cSS and APOE ε2 genotype.
A total of 1412 participants were included in this study; 13 participants had …