Response by Banerjee et al to Letter Regarding Article, “Cognitive Impairment Before Intracerebral Hemorrhage Is Associated With Cerebral Amyloid Angiopathy”
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We thank Cao et al for their interest in our work on the associations of preexisting cognitive impairment in patients with intracerebral hemorrhage.1 We agree that the association between preexisting cognitive impairment and cortical superficial siderosis (cSS) suggests that cSS might directly cause cortical injury or dysfunction through specific toxic effects of iron species or hemosiderin deposition. However, we think that the magnitude and direction of the associations between strictly lobar microbleeds (odds ratio, 2.47; 95% confidence interval, 0.95–6.37) and lobar intracerebral hemorrhage (odds ratio, 2.29; 95% confidence interval, 0.99–5.31) are also likely to be important for cognitive function although they did not reach statistical significance because of our relatively small sample …