Response by Ntaios et al to Letter Regarding Article, “Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis”
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We thank Chen et al1 for suggesting further subgroup analyses, using network meta-analysis, and adding nonrandomized data to our study.2
We agree that separate analyses of patients according to shunt size and the presence or absence of atrial septal aneurysm could provide further insight into the relative impact of the closure of patent foramen ovale. These and other subgroup analyses might be most appropriately performed with individual patient data from all randomized clinical trials of patent foramen ovale closure, as has been done …