Letter by Bhargava Regarding Article, “Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Major Vascular Events”
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To the Editor:
In their article, “Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Major Vascular Events,” Lee et al1 compared the magnitudes of coefficients of systolic, diastolic, and pulse pressures for the probabilities of stroke, myocardial infarction, and all-cause death among South Korean patients. Although pulse pressure may be a good indicator of arterial stiffness, Lee et al used incorrect statistical procedures to conclude that pulse pressure is a better predictor than systolic and diastolic blood pressures. The authors overlooked the fact that pulse pressure is a linear combination of systolic and diastolic blood pressures so that models containing pulse pressures are nested inside a general model where systolic and diastolic blood pressures are included as …