A Paradoxical Cerebral Hemodynamic Effect of Hydralazine
Hydralazine is shown to have a very complex cerebral hemodynamic effect. It raises the intracranial pressure which, together with its effect upon systemic blood pressure, reduces the cerebral perfusion pressure. In spite of this and a concomitantly induced hyperventilation by hydralazine, CBF increases with some delay. The conclusion is that hydralazine is a cerebral vasodilator acting immediately upon cerebral capacitance vessels but later upon the resistance vessels as well.
- regional cerebral blood flow
- intracranial pressure
- cerebral capacitance vessels
- cerebral resistance vessels
- © 1975 American Heart Association, Inc.