A Classification of Experimental Models of Brain Ischemia
A system is presented for the classification of experimental models of cerebral ischemia by a mechanism of induction and distribution of the cerebral insult. Application of the proposed system to the scientific literature may help to resolve apparent conflicts in experimental findings and establish a frame of reference upon which to estimate the relevance of specific animal data to clinical phenomena. Experimental ischemic lesions and pathophysiological states must be considered the net product of variables in etiology and distribution of ischemia in the species chosen under the specific anesthesia selected.
Section on Head Injury and Stroke, Applied Neurologic Research Branch, Collaborative and Field Research, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Building 36, Room 4A03, Bethesda, Maryland 20014.
- Copyright © 1976 by American Heart Association