Corpus Callosum and Experimental Stroke
Studies in Callosotomized Rats and Acallosal Mice
Background and Purpose—Interhemispheric inhibition via the corpus callosum has been proposed as an exacerbating factor in outcome from stroke.
Methods—We measured infarct volume and behavioral outcome after middle cerebral artery occlusion in callosotomized rats and acallosal mice.
Results—Neither callosotomy in rats nor callosal agenesis in mice improved infarct volume or behavioral outcome after middle cerebral artery occlusion.
Conclusions—These findings argue against a role for transcallosal projections in exacerbating focal cerebral ischemia.
- Received January 5, 2011.
- Accepted March 28, 2011.
- © 2011 American Heart Association, Inc.