Increased Frequency of First-Episode Poststroke Depression After Discontinuation of Escitalopram
Background and Purpose—The purpose of this study was to compare escitalopram, problem-solving therapy, and placebo to prevent poststroke depression during 6 months after discontinuation of treatment.
Methods—We examined for depression 33 patients assigned to placebo, 34 to escitalopram, and 41 to problem-solving therapy.
Results—After controlling for age, gender, prior mood disorder, and severity of stroke, new-onset major depression and Hamilton Depression scores were significantly higher 6 months after escitalopram was discontinued compared with the problem-solving therapy or placebo groups.
Conclusions—Discontinuation of escitalopram may increase poststroke depressive symptoms.
- Received May 18, 2011.
- Accepted May 20, 2011.
- © 2011 American Heart Association, Inc.