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Original Contributions

Short-Term Effect of Atorvastatin on Carotid Artery Elasticity

A Pilot Study

Elizabeth V. Ratchford, Jose Gutierrez, Dalia Lorenzo, Mark S. McClendon, David Della-Morte, Janet T. DeRosa, Mitchell S.V. Elkind, Ralph L. Sacco, Tatjana Rundek
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https://doi.org/10.1161/STROKEAHA.111.625418
Stroke. 2011;STROKEAHA.111.625418
Originally published September 8, 2011
Elizabeth V. Ratchford
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Jose Gutierrez
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Dalia Lorenzo
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Mark S. McClendon
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David Della-Morte
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Janet T. DeRosa
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Mitchell S.V. Elkind
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Ralph L. Sacco
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Tatjana Rundek
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Abstract

Background and Purpose—Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound.

Methods—The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70±7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter−diastolic diameter)/diastolic diameter], stiffness (β) [ln (systolic/diastolic blood pressure)/strain], and distensibility (1/β adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at α=0.05.

Results—Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06–0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04–0.06; P<0.01). Mean baseline distensibility was 15.25 (CI, 13.18–17.32), increasing significantly at day 30 to 17.23 (CI, 14.01–20.45; P<0.05). An improvement in distensibility of ≥10% from baseline was observed in 29 (73%) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels <130 mg/dL.

Conclusions—Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.

  • carotid arteries
  • carotid ultrasound
  • elasticity
  • statins
  • Received May 7, 2011.
  • Accepted June 17, 2011.
  • © 2011 American Heart Association, Inc.

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    Short-Term Effect of Atorvastatin on Carotid Artery Elasticity
    Elizabeth V. Ratchford, Jose Gutierrez, Dalia Lorenzo, Mark S. McClendon, David Della-Morte, Janet T. DeRosa, Mitchell S.V. Elkind, Ralph L. Sacco and Tatjana Rundek
    Stroke. 2011;STROKEAHA.111.625418, originally published September 8, 2011
    https://doi.org/10.1161/STROKEAHA.111.625418

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    Short-Term Effect of Atorvastatin on Carotid Artery Elasticity
    Elizabeth V. Ratchford, Jose Gutierrez, Dalia Lorenzo, Mark S. McClendon, David Della-Morte, Janet T. DeRosa, Mitchell S.V. Elkind, Ralph L. Sacco and Tatjana Rundek
    Stroke. 2011;STROKEAHA.111.625418, originally published September 8, 2011
    https://doi.org/10.1161/STROKEAHA.111.625418
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