Cerebral Atrophy is an Independent Risk Factor for Unfavorable Outcome After Spontaneous Supratentorial Intracerebral Hemorrhage
Background and Purpose—To investigate the influence of cerebral atrophy on clinical outcome in patients with supratentorial intracerebral hemorrhage.
Methods—Computed tomography scans of 320 patients included in a prospective, multicenter trial were used for a segmentation analysis to determine the supratentorial cerebral volume. A logistic regression analysis was used to explore its effect on outcome after 90 days in addition to other clinical and imaging parameters.
Results—Cerebral volume loss significantly reduced the odds for favorable outcome after 90 days (odds ratio=0.91; confidence interval, 0.85–0.99; P=0.02).
Conclusions—Cerebral atrophy is an independent predictor of unfavorable outcome after intracerebral hemorrhage, indicating reduced functional recovery potential in these individuals.
- Received July 13, 2012.
- Revision received December 8, 2012.
- Accepted December 31, 2012.
- © 2013 American Heart Association, Inc.