Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage
Nested Case-Control Study
Background and Purpose—Fibroblast growth factor 23 (FGF23) is a hormone with regulatory effects on mineral metabolism and arterial calcification. We aimed to study the association between FGF23 and risk of incident subarachnoid hemorrhage (SAH) in a nested case-control study.
Methods—FGF23 was analyzed in stored blood samples from incident SAH cases (n=79) and control subjects (n=232), participating in the prospective, population-based Malmö Diet and Cancer Study. The association between FGF23 and SAH was studied using conditional logistic regression.
Results—High FGF23 was associated with incident SAH. In the highest compared with the lowest quartile of FGF23, the odds ratio for SAH was 3.28 (95% confidence interval, 1.34–8.00), P for trend=0.006, after adjustment for SAH risk factors.
Conclusions—High FGF23 was associated with increased risk of incident SAH in subjects from the general population. Further studies should elucidate whether FGF23 is a causal risk factor for SAH, or could be used in risk prediction.
- Received June 25, 2015.
- Revision received August 21, 2015.
- Accepted August 26, 2015.
- © 2015 American Heart Association, Inc.