Understanding and Applying the New Endovascular Trials

The results of the four recently presented/published trials for acute ischemic stroke herald the dawn of a new era in the treatment of patients with large vessel occlusion amenable to endovascular intervention. Additional trials are underway or have been stopped earlier because of the positive results observed in the initial trials. Hopefully, the ongoing trials will largely amplify and build upon the results observed in the MR CLEAN, ESCAPE, EXTEND-IA and SWIFT PRIME trials. At this time, it is important for the medical community, health care planners and policy makers to have interpretation and guidance from experts about the trial results currently available for help in steering them as to how the trial results should be utilized in daily practice and for the local organization of acute stroke care. To accomplish this goal, Stroke invited a panel of experts with a wide range of backgrounds to provide insights. . . .

Editorial: The Dawning of a New Era in Acute Stroke Therapy
Marc Fisher and Ajay Wakhloo
Extract | PDF

Interventionalist Perspective on the New Endovascular Trials
Laurent Pierot and Colin Derdeyn
Abstract | PDF

Stroke Neurologist's Perspective on the New Endovascular Trials
James C. Grotta and Werner Hacke
Abstract | PDF

The Relevance of Imaging in Current Acute Ischemic Stroke Workflow for Endovascular Therapy
Bijoy K. Menon, Bruce C.V. Campbell, Christopher Levi, and Mayank Goyal
Abstract | PDF

Endovascular Clot Retrieval Therapy: Implications for the Organization of Stroke Systems of Care in North America
Eric E. Smith and Lee H. Schwamm
Abstract | PDF

Implication of the Recent Positive Endovascular Intervention Trials for Organizing Acute Stroke Care: European Perspective
Turgut Tatlisumak
Abstract | PDF

Acute Reperfusion Therapy and Stroke Care in Asia after Successful Endovascular Trials
Kazunori Toyoda, Masatoshi Koga, Mikito Hayakawa, and Hiroshi Yamagami
Abstract | PDF