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Volume 34, Issue 8; August 1, 2003
Original Contributions
Research Reports
Comments, Opinions, and Reviews
Letters to the Editor
Controversies in Stroke
Corrections
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Original Contributions
Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke
Randall T. Higashida and Anthony J. Furlan
Stroke. 2003;34:e109-e137; published online before print July 17 2003, doi:10.1161/01.STR.0000082721.62796.09.
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Ethnic Differences in Markers of Thrombophilia: Implications for the Investigation of Ischemic Stroke in Multiethnic Populations: The South London Ethnicity and Stroke Study
Paula Jerrard-Dunne, Andrew Evans, Rory McGovern, Cother Hajat, Lalit Kalra, Anthony G. Rudd, Charles D. Wolfe, and Hugh S. Markus
Stroke. 2003;34:1821-1826; published online before print July 3 2003, doi:10.1161/01.STR.0000083049.65008.5F.
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Editorial CommentRoutine Thrombophilia Testing in Stroke Patients Is Unjustified
Graeme J. Hankey and John W. Eikelboom
Stroke. 2003;34:1826-1827; published online before print July 3 2003, doi:10.1161/01.STR.0000083533.81284.0B.
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Cause-Specific Mortality After First Cerebral Infarction: A Population-Based Study
Steven Vernino, Robert D. Brown, Jr, James J. Sejvar, JoRean D. Sicks, George W. Petty, and W. Michael OFallon
Stroke. 2003;34:1828-1832; published online before print July 10 2003, doi:10.1161/01.STR.0000080534.98416.A0.
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Are Changes in Mortality From Stroke Caused by Changes in Stroke Event Rates or Case Fatality?: Results From the WHO MONICA Project
Cinzia Sarti, Birgitta Stegmayr, Hanna Tolonen, Markku Mähönen, Jaakko Tuomilehto, and Kjell Asplund
Stroke. 2003;34:1833-1840; published online before print July 10 2003, doi:10.1161/01.STR.0000081224.15480.52.
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Editorial CommentExplanations for International Trends in Stroke Mortality
Rainer Fogelholm
Stroke. 2003;34:1840-1841; published online before print July 17 2003, doi:10.1161/01.STR.0000085565.91317.4C.
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Ten-Year Survival After First-Ever Stroke in the Perth Community Stroke Study
Kate Hardie, Graeme J. Hankey, Konrad Jamrozik, Robyn J. Broadhurst, and Craig Anderson
Stroke. 2003;34:1842-1846; published online before print July 3 2003, doi:10.1161/01.STR.0000082382.42061.EE.
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Risk, Types, and Severity of Intracranial Hemorrhage in Patients With Symptomatic Carotid Artery Stenosis
Raymond T.F. Cheung, Michael Eliasziw, Heather E. Meldrum, Allan J. Fox, and Henry J.M. Barnett
Stroke. 2003;34:1847-1851; published online before print June 26 2003, doi:10.1161/01.STR.0000080523.29138.5F.
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Prehemorrhage Risk Factors for Fatal Intracranial Aneurysm Rupture
Seppo Juvela
Stroke. 2003;34:1852-1857; published online before print June 26 2003, doi:10.1161/01.STR.0000080380.56799.DD.
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Editorial CommentPrehemorrhage Risk Factors for Fatal Intracranial Aneurysm Rupture
J. Max Findlay
Stroke. 2003;34:1857-1858; published online before print July 17 2003, doi:10.1161/01.STR.0000085566.16190.ED.
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Risk Factors for Continued Cigarette Use After Subarachnoid Hemorrhage
Jennifer Ballard, Kurt T. Kreiter, Jan Claassen, Robert G. Kowalski, E. Sander Connolly, and Stephan A. Mayer
Stroke. 2003;34:1859-1863; published online before print July 3 2003, doi:10.1161/01.STR.0000080522.36041.9F.
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Multiple Levels of Regulation of the Interleukin-6 System in Stroke
Daniela Acalovschi, Tina Wiest, Marius Hartmann, Maryam Farahmi, Ulrich Mansmann, Gerd U. Auffarth, Armin J. Grau, Fiona R. Green, Caspar Grond-Ginsbach, and Markus Schwaninger
Stroke. 2003;34:1864-1869; published online before print July 3 2003, doi:10.1161/01.STR.0000079815.38626.44.
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Editorial CommentHow to Search for the Role of Genetic Polymorphisms in Stroke: Theory Versus Practice
Mario Di Napoli
Stroke. 2003;34:1869-1870; published online before print July 3 2003, doi:10.1161/01.STR.0000079816.60008.73.
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Effect of Aging on Dynamic Cerebral Autoregulation During Head-Up Tilt
Brian J. Carey, Ronney B. Panerai, and John F. Potter
Stroke. 2003;34:1871-1875; published online before print July 10 2003, doi:10.1161/01.STR.0000081981.99908.F3.
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Assessment of Cerebral Blood Flow by Means of Blood-Flow-Volume Measurement in the Internal Carotid Artery: Comparative Study With a
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Xenon Clearance Technique
J.F. Soustiel, T.C. Glenn, P. Vespa, B. Rinsky, C. Hanuscin, and N.A. Martin
Stroke. 2003;34:1876-1880; published online before print July 3 2003, doi:10.1161/01.STR.0000080942.32331.39.
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Dynamic Autoregulation Testing in Patients With Middle Cerebral Artery Stenosis
C. Haubrich, W. Kruska, R.R. Diehl, W. Möller-Hartmann, and C. Klötzsch
Stroke. 2003;34:1881-1885; published online before print July 3 2003, doi:10.1161/01.STR.0000080936.36601.34.
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Evaluation of Hyperintense Vessels on FLAIR MRI for the Diagnosis of Multiple Intracerebral Arterial Stenoses
Daniela Iancu-Gontard, Catherine Oppenheim, Emmanuel Touzé, Eric Méary, Mathieu Zuber, Jean-Louis Mas, Daniel Frédy, and Jean-François Meder
Stroke. 2003;34:1886-1891; published online before print June 26 2003, doi:10.1161/01.STR.0000080382.61984.FE.
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Prediction of Malignant Middle Cerebral Artery Infarction by Early Perfusion- and Diffusion-Weighted Magnetic Resonance Imaging
Götz J. Thomalla, Thomas Kucinski, Volker Schoder, Jens Fiehler, Rene Knab, Herrmann Zeumer, Cornelius Weiller, and Joachim Röther
Stroke. 2003;34:1892-1899; published online before print July 10 2003, doi:10.1161/01.STR.0000081985.44625.B6.
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Editorial CommentCan We Predict Massive Space-Occupying Edema in Large Hemispheric Infarctions?
Christine A.C. Wijman
Stroke. 2003;34:1899-1900; published online before print July 10 2003, doi:10.1161/01.STR.0000081986.02572.D5.
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Relative Value of Normalized Sonographic In Vitro Analysis of Arteriosclerotic Plaques of Internal Carotid Artery
Christian Denzel, Klaus Balzer, Klaus-Michael Müller, Franz Fellner, Claudia Fellner, and Werner Lang
Stroke. 2003;34:1901-1906; published online before print July 10 2003, doi:10.1161/01.STR.0000081982.85010.A8.
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Operational Definitions for the NINDS-AIREN Criteria for Vascular Dementia: An Interobserver Study
Elisabeth C.W. van Straaten, Philip Scheltens, Dirk L. Knol, Mark A. van Buchem, Ewout J. van Dijk, Paul A.M. Hofman, Giorgos Karas, Olafur Kjartansson, Frank-Erik de Leeuw, Niels D. Prins, Reinhold Schmidt, Marieke C. Visser, Henry C. Weinstein, and Frederik Barkhof
Stroke. 2003;34:1907-1912; published online before print July 10 2003, doi:10.1161/01.STR.0000083050.44441.10.
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Development and Progression of Leukoaraiosis in Patients With Brain Ischemia and Carotid Artery Disease
Jonathan Y. Streifler, Michael Eliasziw, Oscar R. Benavente, Sonia Alamowitch, Allan J. Fox, Vladimir Hachinski, and Henry J.M. Barnett
Stroke. 2003;34:1913-1916; published online before print July 17 2003, doi:10.1161/01.STR.0000080939.39414.83.
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Editorial CommentThe Progression of Leukoaraiosis
J.V. Bowler
Stroke. 2003;34:1916-1917; published online before print July 17 2003, doi:10.1161/01.STR.0000080940.16070.5B.
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Feasibility of Neuroprotective Agent Administration by Prehospital Personnel in an Urban Setting
Todd Crocco, Travis Gullett, Stephen M. Davis, Nicole Flores, Laura Sauerbeck, Edward Jauch, Billie Threlkeld, Brian Pio, Michael Ottaway, Arthur Pancioli, and Thomas Chenier
Stroke. 2003;34:1918-1922; published online before print July 3 2003, doi:10.1161/01.STR.0000080943.59701.0D.
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Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke
Randall T. Higashida and Anthony J. Furlan
Stroke. 2003;34:1923-1924, doi:10.1161/01.STR.0000082720.85129.0A.
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Selection of Acute Ischemic Stroke Patients for Intra-Arterial Thrombolysis With Pro-Urokinase by Using ASPECTS
Michael D. Hill, Howard A. Rowley, Felix Adler, Michael Eliasziw, Anthony Furlan, Randall T. Higashida, Lawrence R. Wechsler, Heidi C. Roberts, William P. Dillon, Nancy J. Fischbein, Carolyn M. Firszt, Gregory A. Schulz, and Alastair M. Buchan
Stroke. 2003;34:1925-1931; published online before print July 3 2003, doi:10.1161/01.STR.0000082483.37127.D0.
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Thrombolysis With Recombinant Tissue Plasminogen Activator and Tirofiban in Stroke: Preliminary Observations
Rüdiger J. Seitz, Magnolia Hamzavi, Ulrich Junghans, Peter A. Ringleb, Corinna Schranz, and Mario Siebler
Stroke. 2003;34:1932-1935; published online before print June 26 2003, doi:10.1161/01.STR.0000080535.61188.A6.
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Protected Carotid Stenting: Clinical Advantages and Complications of Embolic Protection Devices in 442 Consecutive Patients
Alberto Cremonesi, Raffaella Manetti, Francesco Setacci, Carlo Setacci, and Fausto Castriota
Stroke. 2003;34:1936-1941; published online before print July 3 2003, doi:10.1161/01.STR.0000081000.23561.61.
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Editorial CommentCarotid Artery Stenting With or Without Protection Devices? Strong Opinions, Poor Evidence!
Bernd Eckert and Hermann Zeumer
Stroke. 2003;34:1941-1943; published online before print July 3 2003, doi:10.1161/01.STR.0000080938.80364.75.
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Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39): Evaluation of Acceptability, Reliability, and Validity
Katerina Hilari, Sally Byng, Donna L. Lamping, and Sarah C. Smith
Stroke. 2003;34:1944-1950; published online before print July 10 2003, doi:10.1161/01.STR.0000081987.46660.ED.
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Serum Urate as an Independent Predictor of Poor Outcome and Future Vascular Events After Acute Stroke
Christopher J. Weir, Scott W. Muir, Matthew R. Walters, and Kennedy R. Lees
Stroke. 2003;34:1951-1956; published online before print July 3 2003, doi:10.1161/01.STR.0000081983.34771.D2.
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Editorial CommentElevated Uric Acid and Ischemic Stroke: Accumulating Evidence That It Is Injurious and Not Neuroprotective
John Kanellis and Richard J. Johnson
Stroke. 2003;34:1956-1957; published online before print July 3 2003, doi:10.1161/01.STR.0000081984.07414.EF.
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Primary Care, Income Inequality, and Stroke Mortality in the United States: A Longitudinal Analysis, 19851995
Leiyu Shi, James Macinko, Barbara Starfield, Jiahong Xu, and Robert Politzer
Stroke. 2003;34:1958-1964; published online before print July 3 2003, doi:10.1161/01.STR.0000082380.80444.A9.
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Advertising Strategies to Increase Public Knowledge of the Warning Signs of Stroke
Frank L. Silver, Frank Rubini, Diane Black, and Corinne S. Hodgson
Stroke. 2003;34:1965-1968; published online before print July 10 2003, doi:10.1161/01.STR.0000083175.01126.62.
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Editorial CommentAdvertising Strategies to Increase the Public Knowledge of the Warning Signs of Stroke
Larry B. Goldstein
Stroke. 2003;34:1968-1969; published online before print July 17 2003, doi:10.1161/01.STR.0000085293.12506.2C.
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Sex Differences in Management and Outcome After Stroke: A Swedish National Perspective
Eva-Lotta Glader, Birgitta Stegmayr, Bo Norrving, Andreas Terént, Kerstin Hulter-Åsberg, Per-Olov Wester, and Kjell Asplund
Stroke. 2003;34:1970-1975; published online before print July 10 2003, doi:10.1161/01.STR.0000083534.81284.C5.
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Cerebral Ischemia and Infarction From Atheroemboli <100 µm in Size
Joseph H. Rapp, Xian Mang Pan, Bo Yu, Raymond A. Swanson, Randall T. Higashida, Paul Simpson, and David Saloner
Stroke. 2003;34:1976-1980; published online before print July 10 2003, doi:10.1161/01.STR.0000083400.80296.38.
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Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin
Konstantin Prass, Anna Scharff, Karsten Ruscher, Diana Löwl, Claudia Muselmann, Ilya Victorov, Krisztian Kapinya, Ulrich Dirnagl, and Andreas Meisel
Stroke. 2003;34:1981-1986; published online before print June 26 2003, doi:10.1161/01.STR.0000080381.76409.B2.
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Astrocytic Gap Junctions Composed of Connexin 43 Reduce Apoptotic Neuronal Damage in Cerebral Ischemia
Taizen Nakase, Shinji Fushiki, and Christian C.G. Naus
Stroke. 2003;34:1987-1993; published online before print July 3 2003, doi:10.1161/01.STR.0000079814.72027.34.
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Ultrarapid, Convection-Enhanced Intravascular Hypothermia: A Feasibility Study in Nonhuman Primate Stroke
William J. Mack, Judy Huang, Christopher Winfree, Grace Kim, Marcelo Oppermann, John Dobak, Becky Inderbitzen, Steve Yon, Sulli Popilskis, Juan Lasheras, Robert R. Sciacca, David J. Pinsky, and E. Sander Connolly, Jr
Stroke. 2003;34:1994-1999; published online before print June 26 2003, doi:10.1161/01.STR.0000079813.31539.6D.
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Drug-Induced Hypothermia Reduces Ischemic Damage: Effects of the Cannabinoid HU-210
Ronen R. Leker, Naomi Gai, Raphael Mechoulam, and Haim Ovadia
Stroke. 2003;34:2000-2006; published online before print June 26 2003, doi:10.1161/01.STR.0000079817.68944.1E.
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Prophylactic but Not Delayed Administration of Simvastatin Protects Against Long-Lasting Cognitive and Morphological Consequences of Neonatal Hypoxic-Ischemic Brain Injury, Reduces Interleukin-1ß and Tumor Necrosis Factor-
mRNA Induction, and Does Not Affect Endothelial Nitric Oxide Synthase Expression
Walter Balduini, Erika Mazzoni, Silvia Carloni, Maria Grazia De Simoni, Carlo Perego, Luigi Sironi, and Mauro Cimino
Stroke. 2003;34:2007-2012; published online before print June 26 2003, doi:10.1161/01.STR.0000080677.24419.88.
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Ebselen, a Seleno-Organic Antioxidant, Is Neuroprotective After Embolic Strokes in Rabbits: Synergism With Low-Dose Tissue Plasminogen Activator
Paul A. Lapchak and Justin A. Zivin
Stroke. 2003;34:2013-2018; published online before print July 10 2003, doi:10.1161/01.STR.0000081223.74129.04.
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Differences in Clot Preparation Determine Outcome of Recombinant Tissue Plasminogen Activator Treatment in Experimental Thromboembolic Stroke
Frank Niessen, Thomas Hilger, Mathias Hoehn, and Konstantin-A. Hossmann
Stroke. 2003;34:2019-2024; published online before print July 3 2003, doi:10.1161/01.STR.0000080941.73934.30.
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Closure of the Blood-Brain Barrier by Matrix Metalloproteinase Inhibition Reduces rtPA-Mediated Mortality in Cerebral Ischemia With Delayed Reperfusion
Thomas Pfefferkorn and Gary A. Rosenberg
Stroke. 2003;34:2025-2030; published online before print July 10 2003, doi:10.1161/01.STR.0000083051.93319.28.
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Matrix and Bioabsorbable Polymeric Coils Accelerate Healing of Intracranial Aneurysms: Long-Term Experimental Study
Yuichi Murayama, Satoshi Tateshima, Nestor R. Gonzalez, and Fernando Vinuela
Stroke. 2003;34:2031-2037; published online before print July 17 2003, doi:10.1161/01.STR.0000083394.33633.C2.
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Angiotensin II Produces Superoxide-Mediated Impairment of Endothelial Function in Cerebral Arterioles
Sean P. Didion and Frank M. Faraci
Stroke. 2003;34:2038-2042; published online before print June 26 2003, doi:10.1161/01.STR.0000081225.46324.AA.
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Argatroban Attenuates Leukocyte and PlateletEndothelial Cell Interactions After Transient Retinal Ischemia
Shinsuke Miyahara, Junichi Kiryu, Akitaka Tsujikawa, Hideto Katsuta, Kazuaki Nishijima, Kazuaki Miyamoto, Kenji Yamashiro, Atsushi Nonaka, and Yoshihito Honda
Stroke. 2003;34:2043-2049; published online before print July 17 2003, doi:10.1161/01.STR.0000083052.01361.3D.
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Research Reports
Very Early Risk of Stroke After a First Transient Ischemic Attack
J.K. Lovett, M.S. Dennis, P.A.G. Sandercock, J. Bamford, C.P. Warlow, and P.M. Rothwell
Stroke. 2003;34:e138-e140; published online before print July 10 2003, doi:10.1161/01.STR.0000080935.01264.91.
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Editorial CommentStroke Following TIA: Mounting Evidence of Early Risk
Piero Verro
Stroke. 2003;34:e141-e142; published online before print July 17 2003, doi:10.1161/01.STR.0000085294.27928.24.
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Comments, Opinions, and Reviews
Differences in Vascular Risk Factors Between Etiological Subtypes of Ischemic Stroke: Importance of Population-Based Studies
U.G.R. Schulz and P.M. Rothwell
Stroke. 2003;34:2050-2059; published online before print June 26 2003, doi:10.1161/01.STR.0000079818.08343.8C.
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Risk Factors for Intracerebral Hemorrhage in the General Population: A Systematic Review
M.J. Ariesen, S.P. Claus, G.J.E. Rinkel, and A. Algra
Stroke. 2003;34:2060-2065; published online before print July 3 2003, doi:10.1161/01.STR.0000080678.09344.8D.
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Editorial CommentMinor Risk Factors for Intracerebral Hemorrhage: The Jury Is Still Out
Amanda G. Thrift
Stroke. 2003;34:2065-2066; published online before print July 3 2003, doi:10.1161/01.STR.0000080679.40907.5B.
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Leukoaraiosis: An Independent Risk Factor for Stroke?
Domenico Inzitari
Stroke. 2003;34:2067-2071; published online before print June 26 2003, doi:10.1161/01.STR.0000080934.68280.82.
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Cochrane Review: Dipyridamole for Preventing Major Vascular Events in Patients With Vascular Disease
E.L.L.M. De Schryver, A. Algra, and J. van Gijn
Stroke. 2003;34:2072-2080; published online before print July 10 2003, doi:10.1161/01.STR.0000082381.23938.0E.
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Letters to the Editor
Cranial MRI Screening in Healthy Young Men
F. Weber and H. Knopf
Stroke. 2003;34:e99; published online before print July 10 2003, doi:10.1161/01.STR.0000079834.17562.AB.
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The "Dot CT Sign" Indicates MCA Branch Occlusion
David J. Blacker, James C. Watson, and Eelco F.M. Wijdicks
Stroke. 2003;34:e100; published online before print July 10 2003, doi:10.1161/01.STR.0000080944.04893.48.
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New-Onset Fecal Incontinence After Stroke: Risk Factor or Consequence of Poor Outcomes After Rehabilitation?
Juan J. Baztán, Juan R. Domenech, and Margarita González
Stroke. 2003;34:e101-e102; published online before print July 17 2003, doi:10.1161/01.STR.0000081222.82020.D3.
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Re: New Research in the Field of Stroke: Therapeutic Hypothermia After Cardiac Arrest
Response
Michael Holzer, Fritz Sterz, Wilhelm Behringer, W. Dalton Dietrich, and John W. Kuluz
Stroke. 2003;34:e103; published online before print July 17 2003, doi:10.1161/01.STR.0000083469.51522.0C.
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Poor Outcome After First-Ever Stroke
Response
Jagdish C. Sharma, Peter Appelros, Ingegerd Nydevik, and Matti Viitanen
Stroke. 2003;34:e104; published online before print July 10 2003, doi:10.1161/01.STR.0000083467.23040.4B.
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Risk Factors for Pneumonia in Patients With Acute Stroke
Response
Rainer Dziewas, Florian Stögbauer, Peter Lüdemann, R. Hilker, A. Jacobs, M. Neveling, and W.D. Heiss
Stroke. 2003;34:e105; published online before print July 10 2003, doi:10.1161/01.STR.0000083465.17164.AB.
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Cerebral Atherosclerosis and Mild Alzheimers Disease
Hernando Rafael
Stroke. 2003;34:e106; published online before print July 10 2003, doi:10.1161/01.STR.0000083464.56904.E5.
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Re: Pulse Pressure and Risk of Alzheimer Disease in Persons Aged 75 Years and Older
Ernest H. Friedman
Stroke. 2003;34:e107; published online before print July 17 2003, doi:10.1161/01.STR.0000083487.94236.3D.
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Vascular Smooth Muscle Proliferation as a Target for Therapeutic Intervention
Response
J. Marc Simard, Thomas A. Kent, Cecil O. Borel, and Laura Niklason
Stroke. 2003;34:e108; published online before print July 17 2003, doi:10.1161/01.STR.0000082484.19942.C8.
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Controversies in Stroke
Cell Therapy: Replacement
Lawrence R. Wechsler and Douglas Kondziolka
Stroke. 2003;34:2081-2082; published online before print July 24 2003, doi:10.1161/01.STR.0000083461.80316.55.
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Stem Cells: Do They Replace or Stimulate?
David Howells
Stroke. 2003;34:2082-2083; published online before print July 24 2003, doi:10.1161/01.STR.0000083462.47898.DD.
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Stem Cell Transplantation for Stroke: Does It Work, and If So, How?
Marc Fisher
Stroke. 2003;34:2083; published online before print July 24 2003, doi:10.1161/01.STR.0000083463.73181.70.
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Corrections
Correction
Stroke. 2003;34:2084, doi:10.1161/01.STR.0000086704.78941.BD.
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