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Editorials

The Utility of Futility

Imaging the Clot: Does Clot Appearance Predict the Efficacy of Thrombolysis?

Endovascular Revascularization of Symptomatic Acute Extracranial Internal Carotid Artery Occlusion

From Case Study to Prospective Study

Possible Mechanistic Overlap Between Cavernous Malformations and Cerebral Developmental Venous Anomalies

Original Contributions

Evaluation of the Paraoxonases as Candidate Genes for Stroke: Gln192Arg Polymorphism in the Paraoxonase 1 Gene Is Associated With Increased Risk of Stroke

Heritability of the Function and Structure of the Arterial Wall: Findings of the Erasmus Rucphen Family (ERF) Study

Heritability of Carotid Artery Distensibility in Hispanics: The Northern Manhattan Family Study

Time Trends of Ischemic Stroke Incidence and Mortality in Patients Diagnosed With First Atrial Fibrillation in 1980 to 2000: Report of a Community-Based Study

Overnight Changes in the Cerebral Vascular Response to Isocapnic Hypoxia and Hypercapnia in Healthy Humans: Protection Against Stroke

Absence of Microemboli on Transcranial Doppler Identifies Low-Risk Patients With Asymptomatic Carotid Stenosis

Significance of Susceptibility Vessel Sign on T2*-Weighted Gradient Echo Imaging for Identification of Stroke Subtypes

Shape and Volume of Lacunar Infarcts: A 3D MRI Study in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Silent Cerebral Ischemia Detected With Diffusion-Weighted Imaging in Patients Treated With Protected and Unprotected Carotid Artery Stenting

Incidence of Recurrent Subarachnoid Hemorrhage After Clipping for Ruptured Intracranial Aneurysms

Revascularization End Points in Stroke Interventional Trials: Recanalization Versus Reperfusion in IMS-I

Vitamin Intervention for Stroke Prevention Trial: An Efficacy Analysis

Applying a Phase II Futility Study Design to Therapeutic Stroke Trials

Intravenous Heparin Started Within the First 3 Hours After Onset of Symptoms as a Treatment for Acute Nonlacunar Hemispheric Cerebral Infarctions

Outcome and Severe Hemorrhagic Complications of Intravenous Thrombolysis With Tissue Plasminogen Activator in Very Old (80 Years) Stroke Patients

Emergent Stenting of Extracranial Internal Carotid Artery Occlusion in Acute Stroke Has a High Revascularization Rate

Determinants of Staged Endovascular and Surgical Treatment Outcome of Brain Arteriovenous Malformations

When a Parent Has a Stroke: Clinical Course and Prediction of Mood, Behavior Problems, and Health Status of Their Young Children

In-Hospital Medical Complications and Long-Term Mortality After Ischemic Stroke

NIHSS Training and Certification Using a New Digital Video Disk Is Reliable

Variation in the Carotid Bifurcation Geometry of Young Versus Older Adults: Implications for Geometric Risk of Atherosclerosis

Nedd9 Protein, a Cas-L Homologue, Is Upregulated After Transient Global Ischemia in Rats: Possible Involvement of Nedd9 in the Differentiation of Neurons After Ischemia

Cerebral Blood Flow Thresholds for mRNA Synthesis After Focal Ischemia and the Effect of MK-801

Short-Term Administration of a New Free Radical Scavenger, Edaravone, Is More Effective Than its Long-Term Administration for the Treatment of Neonatal Hypoxic–Ischemic Encephalopathy

In Situ ß-Irradiation of a Brain Arteriovenous Malformation Model

Research Reports

Cerebral Venous Malformations Have Distinct Genetic Origin From Cerebral Cavernous Malformations

Electrocardiographic Left Atrial Abnormalities and Risk of Ischemic Stroke

Apolipoprotein E Genotype and Incident Ischemic Stroke: The Atherosclerosis Risk in Communities Study

Perfusion MRI Abnormalities in Speech or Motor Transient Ischemic Attack Patients

Reversal of Dense Signs Predicts Recovery in Acute Ischemic Stroke

Reliability and Validity of the Upper-Extremity Motor Activity Log-14 for Measuring Real-World Arm Use

Poor Outcomes in Patients Who Do Not Receive Intravenous Tissue Plasminogen Activator Because of Mild or Improving Ischemic Stroke

Economic Benefit of Increasing Utilization of Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke in the United States

Case Reports

Thrombolysis Beyond the Guidelines: Two Treatments in One Subject Within 90 Hours Based on a Modified Magnetic Resonance Imaging Brain Clock Concept

Progress Reviews

Low-Grade Carotid Stenosis: Looking Beyond the Lumen With MRI

Supporting Family Caregivers in Stroke Care: A Review of the Evidence for Problem Solving

Letters to the Editor

A Systemic Review of the Risk Factors for Cervical Artery Dissection • Response:

Transcranial Doppler and Carotid Artery Disease Strokes: More Than Just Risk Stratification • Response:

Use of Quantitative Magnetic Resonance Angiography to Stratify Stroke Risk in Symptomatic Vertebrobasilar Disease • Response:

Should We Distinguish Between Periventricular and Deep White Matter Hyperintensities? • Response:

HMG-CoA Reductase Inhibitors Improve Acute Ischemic Stroke Outcome • Response:

Is Neurointensive Care Really Optional for Comprehensive Stroke Care?